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Editorials |

Idiopathic Pulmonary Fibrosis Challenges for the Future

Moisés Selman, MD, FCCP
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Affiliations: Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico 
 ,  Dr. Selman is Director of Research, Instituto Nacional de Enfermedades Respiratorias, Mexico. Corrrespondence to: Moisés Selman, MD, FCCP, Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Sección XVI, México DF, CP 14080, México; e-mail: mselman@conacyt.mx

Affiliations: Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico 
 ,  Dr. Selman is Director of Research, Instituto Nacional de Enfermedades Respiratorias, Mexico. Corrrespondence to: Moisés Selman, MD, FCCP, Instituto Nacional de Enfermedades Respiratorias, Tlalpan 4502, Col. Sección XVI, México DF, CP 14080, México; e-mail: mselman@conacyt.mx



Chest. 2001;120(1):8-10. doi:10.1378/chest.120.1.8
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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually fatal lung disease of no identifiable etiology, characterized by fibroblast proliferation and extracellular matrix accumulation resulting in irreversible distortion of the architecture of the lung.1 IPF has been reported worldwide and does not have predilection by race or ethnicity. Incidence of IPF is estimated to be around 7 cases per 100,000 per year in women and 10 cases per 100,000 per year in men,2 but it increases with older age.3 The disease occurs primarily in individuals between 50 years and 70 years of age, and it appears to be infrequent in young people and extremely rare in children.46 The prevalence of IPF ranges from 13 cases per 100,000 for women to 20 cases per 100,000 for men,2 although these figures may underestimate the problem.

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