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Editorials |

Re-emergence of an “Orphan” Test for Pulmonary Embolism

Charlotte Colp, MD, FCCP; Myron Stein, , MD, FCCP
Author and Funding Information

Affiliations: Albert Einstein College of Medicine, New York, NY 
 ,  UCLA School of Medicine, Los Angeles, CA 
 ,  Dr. Colp is Clinical Associate Professor of Medicine, Albert Einstein College of Medicine, and Dr. Stein is Clinical Professor of Medicine, UCLA School of Medicine.

Correspondence to: Charlotte Colp, MD, 133 East 73 St, New York, NY 10021



Chest. 2001;120(1):5-6. doi:10.1378/chest.120.1.5
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Often clinically suspected, pulmonary embolism (PE) is a potentially fatal disease. Because highly effective but hazardous therapy exists, accurate diagnosis is extremely important. Indeed, much of the research and publications on PE, such as the Prospective Investigation of Pulmonary Embolism Diagnosis study, pertain mainly to methods of diagnosis.

Prior to the development of imaging techniques, the diagnosis of PE was based on a triad of dyspnea, hemoptysis, and chest pain, later shown to be nonspecific and unreliable, for the clinical spectrum can range from no symptoms at all to sudden death. The chest radiograph has been equally nonspecific and unreliable in diagnosis of PE.

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