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Clinical Investigations: CANCER |

Cryotherapy in Early Superficial Bronchogenic Carcinoma*

Nadine Deygas, MD; Marios Froudarakis, MD, FCCP; Gervais Ozenne, MD; Jean-Michel Vergnon, MD, PhD
Author and Funding Information

*From the Service de pneumologie et d’oncologie thoracique (Drs. Deygas, Froudarakis, and Vergnon), Hôpital Nord, Saint-Etienne; and Centre médico chirurgical du cèdre (Dr. Ozenne), Bois-Guillaume, France.

Correspondence to: Jean-Michel Vergnon, MD, PhD, Service de pneumologie et d’oncologie thoracique, Hôpital Nord, Avenue Albert Raimond, 42055 Saint-Etienne Cedex 2, France; e-mail: vergnon@univ-st-etienne.fr



Chest. 2001;120(1):26-31. doi:10.1378/chest.120.1.26
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Background: Treatment of early superficial bronchogenic carcinoma (ESBC) is under debate, and no consensus has been achieved. Different therapeutic methods have been proposed, including surgical resection and endoscopic methods.

Study objective: To assess the efficacy of cryotherapy in patients with ESBC.

Patients and methods: Patients included in the study had histologically proven ESBC after fiberoptic bronchoscopy. Cryotherapy was performed through a rigid bronchoscope. Efficacy was assessed by endoscopy with multiple biopsies 1 month after treatment and during the follow-up period. Parameters studied were response to treatment, adverse effects, and survival.

Results: We included 35 patients (34 men and 1 woman). The mean age was 61 ± 9 years. Multiple locations of ESBC were observed in seven patients (20%). Complete response rate at both 1 month and 1 year was 91% (32 patients). No severe adverse effects were noted. Local recurrence was observed within 4 years in 10 patients (28%). A follow-up period of at least 4 years was available in 22 patients; of them, 11 patients (50%) were long-term survivors.

Conclusion: Our results suggest that cryotherapy is an effective method of treatment in patients with ESBC. Due to its relative tolerance compared to surgery, cryotherapy could be proposed as a first-line therapy in this population with high carcinogenic risk.

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