0
Clinical Investigations: EXERCISE |

Predictors of Oxygen Desaturation During Submaximal Exercise in 8,000 Patients*

Khaled O. Hadeli, MD; Erin M. Siegel, MS; Duane L. Sherrill, PhD; Ken C. Beck, PhD; Paul L. Enright, MD
Author and Funding Information

*From the University of Arizona (Drs. Hadeli, Sherrill, and Enright, and Ms. Siegel), Tucson, AZ; and the Mayo Clinic (Dr. Beck), Rochester, MN.



Chest. 2001;120(1):88-92. doi:10.1378/chest.120.1.88
Text Size: A A A
Published online

Study objectives: To determine predictors of oxygen desaturation during submaximal exercise in patients with various lung diseases.

Design and setting: This retrospective case series used pulmonary function laboratory results from all patients referred to a major tertiary-care center.

Patients and measurements: All patients ≥ 35 years old who underwent spirometry, diffusing capacity of the lung for carbon monoxide (Dlco), lung volumes, and pulse oximetry during 3-min submaximal step-test exercise during 1996 were included (4,545 men and 3,472 women). Logistic regression models, correcting for gender, age, and weight, determined the odds ratios (ORs) for oxygen desaturation of≥ 4% during exercise for each category of lung function abnormality (compared to those with entirely normal lung function).

Results: Approximately 74% of the patients had airways obstruction, while only 5.6% had restriction of lung volumes. One third of those with obstruction had a low Dlco, compared to 56% with restriction, while 2.7% had a low Dlco without obstruction or restriction. The risk of oxygen desaturation during submaximal exercise was very high (OR, 34) in patients with restriction and low Dlco (as in interstitial lung disease) and in patients with obstruction and low Dlco (as in COPD; OR, 18), intermediate (OR, 9) in patients with only a low Dlco, and lowest in those with a normal Dlco (OR, 4 if restricted; OR, 2 if obstructed). A cut point of Dlco< 62% predicted resulted in 75% sensitivity and specificity for exercise desaturation. No untoward cardiac events occurred in any patients during or following the submaximal exercise tests.

Conclusions: The risk of oxygen desaturation during submaximal exercise is very high in patients with a low Dlco. Submaximal exercise tests are safe, even in elderly patients with heart and lung diseases.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543