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Clinical Investigations: EXERCISE |

Sarcoidosis*: The Value of Exercise Testing

Ann E. Medinger, MD, FCCP; Samir Khouri, MD; Prashant K. Rohatgi, MD, FCCP
Author and Funding Information

*From the Pulmonary Physiology Laboratory, Veterans Affairs Medical Center; and Department of Medicine, George Washington University, Washington, DC.

Correspondence to: Ann E. Medinger MD, FCCP, 5605 Park St, Chevy Chase, MD 20815



Chest. 2001;120(1):93-101. doi:10.1378/chest.120.1.93
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Study objectives: To evaluate exercise testing for the assessment of the extent of pulmonary disease in patients with sarcoidosis.

Design: Retrospective analysis of consecutive patients with sarcoidosis referred to the Pulmonary Physiology Laboratory between 1992 and 1997, who completed at least 6 min of progressive bicycle exercise. Resting and exercise pulmonary function measurements were compared to radiographic stage of disease.

Setting: Pulmonary Physiology Laboratory at Washington, DC, Veterans Affairs Medical Center.

Patients: Forty-eight outpatient veterans with biopsy specimen-proven sarcoidosis.

Results: Across all radiographic stages of sarcoidosis, total lung capacity, resting diffusing capacity, and exercise gas exchange measurements had a significant variance with radiographic stage. Across the early radiographic stage disease (stages 0 to 2), the change in alveolar-arterial oxygen pressure gradient between rest and exercise, normalized for oxygen uptake, was the most significant measurement in its variation with radiographic stage.

Conclusions: Changes in gas exchange with exercise may be the most sensitive physiologic measurements to assess the extent of disease in early radiographic stages of sarcoidosis.

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