0
Clinical Investigations: INFECTION |

Prevalence of Asymptomatic Infection With Chlamydia pneumoniae in Subjectively Healthy Adults*

Naoyuki Miyashita, MD, PhD; Yoshihito Niki, MD, PhD, FCCP; Masamitsu Nakajima, MD, PhD, FCCP; Hiroshi Fukano, MD; Toshiharu Matsushima, MD, PhD, FCCP
Author and Funding Information

*From the Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan.

Correspondence to: Naoyuki Miyashita, MD, PhD, Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki City, Okayama 701-0192, Japan; e-mail: nao@med.kawasaki-m.ac.jp



Chest. 2001;119(5):1416-1419. doi:10.1378/chest.119.5.1416
Text Size: A A A
Published online

Study objective: To investigate the prevalence of asymptomatic infection with Chlamydia pneumoniae in subjectively healthy adults.

Design: Prospective study.

Setting: Kawasaki Medical School Hospital in Kurashiki, Japan.

Participants: Total of 1,018 asymptomatic healthy adults (age range, 22 to 50 years; mean age, 32.4 years; 482 men and 536 women).

Measurements and results: Nasopharyngeal swab specimens were obtained from all subjects and analyzed by isolation in cell cultures and polymerase chain reaction (PCR) test for C pneumoniae. Serum samples were also obtained and tested for C pneumoniae-specific antibodies by the microimmunofluorescence test. Of 1,018 specimens tested, 14 specimens (1.4%) were judged positive by culture and/or the PCR. Thirteen specimens were PCR positive, and 4 specimens were culture positive. There were three specimens positive by both tests and 11 specimens positive with discrepancies in culture and PCR results. None of the individuals met the serologic criteria for acute infection. Of 1,018 sera tested, 64.1% of men and 58.0% of women had antibody to C pneumoniae. The overall prevalence of antibody was 60.9%. Forty individuals (3.9%) had an IgG titer of ≥ 1:512 or IgM titer of≥ 1:16.

Conclusions: Our data suggest that asymptomatic infection with Cpneumoniae may occur in subjectively healthy adults.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543