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Special Report |

The Evidence Base for Management of Acute Exacerbations of COPD*: Clinical Practice Guideline, Part 1

Vincenza Snow, MD; Steven Lascher, DVM, MPH; Christel Mottur-Pilson, PhD; for the Joint Expert Panel on COPD of the American College of Chest Physicians and the American College of Physicians-American Society of Internal Medicine
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Affiliations: *From the American College of Physicians-American Society of Internal Medicine and the American College of Chest Physicians. This paper also appears in the Annals of Internal Medicine 2001; 134:595–599.,  A complete list of participants is given in the Appendix.

Correspondence to: Vincenza Snow, MD, American College of Physicians-American Society of Internal Medicine, 190 N. Independence Mall West, Philadelphia, PA 19106; e-mail: Vincenza@Mail.acponline.org



Chest. 2001;119(4):1185-1189. doi:10.1378/chest.119.4.1185
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The American College of Physicians-American Society of Internal Medicine (ACP-ASIM) and the American College of Chest Physicians (ACCP) developed this evidence-based clinical practice guideline in collaboration. A joint ACP-ASIM/ACCP expert panel examined the evidence and developed recommendations. The guideline and accompanying background article are primarily based on a systematic review compiled in an Agency for Health CareResearch and Quality evidence report prepared by the Evidence-Based Practice Center at Duke University.1 Our target audience is primary-care physicians and specialists who care for COPD patients. Although the majority of acute exacerbations of COPD (AE-COPD) take place and are treated on an outpatient basis, the research studies all focus on emergency department (ED) or inpatient settings. As a result, this guideline applies to exacerbations treated in those settings. The guideline presents the available evidence on the following:

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