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Malignant Pleural Mesothelioma Produces Functional Granulocyte-Colony Stimulating Factor*

Ikuma Kasuga, MD; Shirou Ishizuka, MD; Kazushige Minemura, MD; Kenta Utsumi, MD; Hiromi Serizawa, MD; Kazuma Ohyashiki, MD
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*From The First Department of Internal Medicine (Drs. Kasuga, Ishizuka, Minemura, Utsumi, and Ohyashiki), and The Second Department of Pathology (Dr. Serizawa), Tokyo Medical University, Tokyo, Japan.

Correspondence to: Ikuma Kasuga, MD, The First Department of Internal Medicine, Tokyo Medical University, 6–7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan



Chest. 2001;119(3):981-983. doi:10.1378/chest.119.3.981
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We report a patient with diffuse malignant pleural mesothelioma showing marked elevation of neutrophils. The level of serum granulocyte-colony stimulating factor (G-CSF) was elevated (138 pg/mL; normal range,< 20 pg/mL). The patient died 6 weeks after disease progression had been noted, and immunohistochemistry using a specific monoclonal antibody against recombinant G-CSF at autopsy demonstrated that the malignant mesothelioma cells actually produced G-CSF. Only three cases of malignant pleural mesothelioma, including the current patient, have been reported to produce G-CSF. We demonstrated an elevated serum level of G-CSF and G-CSF-bearing tumor cells by immunochemistry.

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