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Multiple Aseptic Pulmonary Nodules With Central Necrosis in Association With Pyoderma Gangrenosum*

Stefan Krüger, MD; Werner Piroth, MD; Baffour Amo-Takyi, MD; Christian Breuer, MD; Ernst R. Schwarz, MD
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*From the Medical Clinic I (Drs. Krüger, Breuer, and Schwarz), Department of Radiology (Dr. Piroth), and Institute of Pathology (Dr. Amo-Takyi), University Hospital, University of Technology, Aachen, Germany.

Correspondence to: Stefan Krüger, MD, Medizinische Klinik I, Universitätsklinikum Rheinisch Westfälische Technische Hochschule, Pauwelsstraβe 30, 52057 Aachen, Germany



Chest. 2001;119(3):977-978. doi:10.1378/chest.119.3.977
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Pulmonary manifestations of pyoderma gangrenosum are relatively rare. We report the case of a 45-year-old patient with multiple pulmonary nodules with central necrosis as assessed by CT scan. The patient had a 4-year history of pyoderma gangrenosum with only minor skin manifestations. A CT-guided, fine-needle biopsy of the lung revealed a nonspecific, inflammatory, aseptic necrotic process, which was comparable to the skin biopsy of one pyoderma lesion. Following the initiation of oral prednisolone therapy, a rapid resolution of the pulmonary nodules occurred. We conclude that pulmonary nodules represent a rare pulmonary manifestation of pyoderma gangrenosum.

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