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Tumor Necrosis Factor Polymorphism in Sarcoidosis

Om P. Sharma, MD, FCCP
Author and Funding Information

Affiliations: Los Angeles, CA 
 ,  Dr. Sharma is Professor of Medicine, Keck School of Medicine of USC, LAC and USC Medical Center.

Correspondence to: Om P. Sharma, MD, FCCP, Keck School of Medicine of USC, LAC and USC Medical Center, 1200 North State St, Room 11900, Los Angeles, CA; 90033; e-mail: osharma@hsc.usc.edu



Chest. 2001;119(3):678-679. doi:10.1378/chest.119.3.678
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Sarcoidosis is an antigen-driven, multisystem, granulomatous disorder, the cause of which is not known. In a genetically susceptible individual, antigen-presenting cells trap, process, and present the putative antigen, in the context of class II major histocompatibility complex (MHC) molecules, to CD4+ lymphocytes. The result of this union is a coordinated release of cytokines and chemokines, which recruit more inflammatory cells (lymphocytes, mononuclear phagocytes, and fibroblasts) and mount a granulomatous response dominated by interferon-γ and interleukin-12.12

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