problem of antimicrobial resistance among clinically relevant pathogens
continues to plague our hospitals. Between 20% and 60% of nosocomial
infections are thought to be caused by antibiotic-resistant bacteria.
Such infections increase patient morbidity and mortality rates and
cause health-care costs to escalate. Critically ill patients in ICUs
are particularly hard-hit by antimicrobial-resistant pathogens. These
clever, single-celled organisms adapt to counteract our repertoire of
antimicrobial artillery at a rate that exceeds our efforts to devise
new strategies to thwart their attack.