Study objectives: To determine if transcatheter
embolotherapy is safe and effective for the treatment of pulmonary
arteriovenous malformations during pregnancy.
Setting: Specialized hereditary
hemorrhagic telangiectasia centers at Yale University School of
Medicine and St. Michael’s Hospital, University of Toronto.
Patients: Seven pregnant women (age range, 24 to 34 years;
gestational age range, 16 to 36 weeks) undergoing transcatheter
embolotherapy in all patients.
results: Thirteen pulmonary arteriovenous malformations in seven
patients were embolized with detachable silicone balloons and/or
stainless steel coils without incident. The estimated fetal radiation
dose ranged from < 50 to 220 mrad. No complications of pulmonary
arteriovenous malformations occurred in any of the patients after
transcatheter embolotherapy. The mothers went on to deliver healthy
babies in all cases.
embolotherapy of maternal pulmonary arteriovenous malformations
performed by an experienced radiologist appears to be safe and
effective after 16 weeks of gestational age.