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Wegener’s Granulomatosis Responding to Antituberculous Drugs*

Mikio Toyoshima, MD; Kingo Chida, MD; Takafumi Suda, MD; Shiro Imokawa, MD; Hirotoshi Nakamura, MD
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*From the Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Correspondence to: Mikio Toyoshima, MD, Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 3600 Handacho, Hamamatsu 431-3192, Japan



Chest. 2001;119(2):643-645. doi:10.1378/chest.119.2.643
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We present a case of Wegener’s granulomatosis (WG) that responded to antituberculous drugs. A 44-year-old woman with multiple nodules on chest radiograph received a diagnosis of pulmonary tuberculosis because open-lung biopsy specimens showed caseous granulomas. Her chest shadows underwent repeated resolution after the start of antituberculous treatment, and relapse after the cessation of the drugs. Antineutrophil cytoplasmic antibody was positive (14 enzyme-linked immunosorbent assay units), and the second lung biopsy specimens showed necrotizing granulomas and vasculitis without pathogenic organisms. Thus, the patient received a diagnosis of WG and was successfully treated with trimethoprim/sulfamethoxazole 10 years after her initial evaluation. Antituberculous drugs were effective in this case of WG.

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