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New Anticoagulant Drugs

Jeffrey I. Weitz, MD; Jack Hirsh, MD
Author and Funding Information

Correspondence to: Jeffrey Weitz, MD, 711 Concession Street, Hamilton, Ontario L8V 1C3, Canada; e-mail: jweitz@thrombosis. hhscr.org



Chest. 2001;119(1_suppl):95S-107S. doi:10.1378/chest.119.1_suppl.95S
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Extract

Arterial and venous thromboses are major causes of morbidity and mortality. Whereas arterial thrombosis is the most common cause of myocardial infarction, stroke, and limb gangrene, venous thrombosis leads to pulmonary embolism, which can be fatal, and to postphlebitic syndrome. Because arterial thrombi consist of platelet aggregates held together by small amounts of fibrin, strategies to inhibit arterial thrombogenesis focus mainly on drugs that block platelet function, but they often include anticoagulants to prevent fibrin deposition. In contrast, anticoagulants are the drugs of choice for prevention of cardioembolic events. Anticoagulants also are used for prevention and treatment of venous thrombosis, because venous thrombi are comprised mainly of fibrin and RBCs.

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  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543