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The Sixth (2000) ACCP Guidelines for Antithrombotic Therapy for Prevention and Treatment of Thrombosis

Jack Hirsh, MD, FCCP; James E. Dalen, MD, MPM, Master FCCP; Gordon Guyatt, MD
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Correspondence to: James E. Dalen, MD, MPH, Master FCCP, 1501 N Campbell Avenue, Tucson, AZ 85724-7384



Chest. 2001;119(1_suppl):1S-2S. doi:10.1378/chest.119.1_suppl.1S
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Thrombosis , an important complication of atherosclerosis and of various medical and surgical conditions, can be prevented or treated effectively by a variety of pharmacologic agents. Three classes of agents are available: anticoagulants, antiplatelet agents, and thrombolytic drugs. The first two prevent the formation and growth of thrombi, whereas the third lyses existing thrombi.

The American College of Chest Physicians (ACCP) Task Force on Antithrombotic Therapy published the proceedings of their first consensus conference on antithrombotic therapy in 1986.1 The participants introduced a system of evidence that has served as a model for critically appraising the literature and has been adopted by many medical organizations. In the 14 years since the first conference, the field of antithrombotic therapy has witnessed enormous growth, due in part to the development of new and more powerful pharmacologic agents and in part to the evaluation of these agents in well-designed clinical trials. The proceedings of the sixth ACCP Consensus Conference provide an extensive critical review of the literature related to management of thromboembolic disorders, including venous thromboembolism, arterial thrombosis, and systemic arterial embolism. As in past reports, each section concludes with a detailed summary that documents the therapeutic recommendations, assigns a grade for each recommendation (1 or 2), and proffers the strength of the evidence on which the recommendations are based (A,B,C, or C+).

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