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Prevention of Venous Thromboembolism

William H. Geerts, MD, FCCP, Chair; John A. Heit, MD; G. Patrick Clagett, MD; Graham F. Pineo, MD, FCCP; Clifford W. Colwell, MD; Frederick A. Anderson, Jr., PhD; H. Brownell Wheeler, MD
Author and Funding Information

Affiliations: *Dr. Geerts receives research funding from Aventis Pharma, Pharmacia & Upjohn. ,  Dr. Heit receives research funding from AstraZeneca, Aventis Pharma, Corvas, DuPont Pharma, and Wyeth-Ayerst. ,  Dr. Pineo receives research funding from DuPont Pharma, Emesphere Technologies, Leo Pharma, and Pharmacia & Upjohn. Dr. Pineo also serves on the advisory boards for Pharmacia & Upjohn and DuPont Pharma. ,  §Dr. Colwell receives research funding from and serves as consultant for Rhone-Poulenc Rorer, Pharmacia & Upjohn, and AstraZeneca. ,  Dr. Anderson receives research funding from and serves as consultant for Aventis Pharma.

Correspondence to: William H. Geerts, MD, Thromboembolism Program, Sunnybrook & Women’s College Health Sciences Centre, Room D674, 2075 Bayview Ave., Toronto, ON, Canada, M4N 3M5.



Chest. 2001;119(1_suppl):132S-175S. doi:10.1378/chest.119.1_suppl.132S
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This chapter reviews the literature related to the risks of VTE and its prevention. For each patient group, literature searches have been conducted and a priori criteria for inclusion of studies have been applied to derive quantitative estimates of the baseline risks of thromboembolism and the efficacy of each of the prophylaxis interventions (Table 1). In the summary tables, the rates of deep vein thrombosis have been pooled from the eligible trials for each intervention and then compared with the rate among pooled, untreated, or placebo-treated control patients to determine the reduction in relative risk. Because comparisons among the interventions are indirect, the results of this pooling analysis provide an approximate guide to the relative efficacy of various prophylactic strategies. The final recommendations are based on the results of our pooled data as well as major randomized trials and/or formal, published meta-analyses. Although the recommendations are evidence-based, where possible, practical suggestions for prophylaxis are provided, particularly in situations where the evidence is inadequate.

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  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543