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Communications to the Editor |

Endothelial Apoptosis FREE TO VIEW

Ken-ichiro Inoue, MD; Yutaka Kawahito, MD, PhD; Hajime Sano, MD, PhD
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Kyoto Prefectural University of Medicine Kyoto-city, Japan

Correspondence to: Ken-ichiro Inoue, MD, First Department of Internal Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kyoto-city, 602-8566, Japan; e-mail: keni@kk.ii4u.or.jp



Chest. 2000;118(6):1839. doi:10.1378/chest.118.6.1839
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To the Editor:

We read with interest the excellent review by Stefanec (March 2000),1which summarized the knowledge about endothelial apoptosis. Table 2 of his article represented the pro- and antiapoptotic stimuli for endothelial cells. Herein, we would like to add activating a topic receptor as a proapoptotic stimulus for its cells in the Table. Activation of peroxisome proliferator-activated receptor (PPAR)-γ is also recognized to induce endothelial apoptosis.2PPARs are members of the nuclear hormone receptors superfamily of ligand-activated transcriptional factors that include receptors for steroids, thyroid hormone, vitamin D, and retinoic acid.3Among PPARs (-α, -γ, and -δ), PPAR-γ is expressed in adipose tissue and the immune system such as the splenocytes, monocytes, and bone marrow precursors,4 and it plays important roles in adipocyte differentiation, anti-inflammatory process, and growth arrest of tumor cells.5 In addition, recent data have shown that natural prostaglandin 15-deoxy-δ12,14-prostaglandin J2 and the synthetic antidiabetic thiazolidinediones, which are PPAR-γ ligands, induce apoptosis in macrophages, fibroblasts, cancer cells, and endothelial cells.,2,56 Hence, PPAR-γ may become a novel therapeutic target as a proapoptotic stimulus.

References

Stefanec, T (2000) Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease?Chest117,841-854. [CrossRef] [PubMed]
 
Bishop-Bailey, D, Hla, T Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta 12, 14-prostaglandin J 2.J Biol Chem1999;274,17042-17048. [CrossRef] [PubMed]
 
Issemann, I, Green, S Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.Nature1990;347,645-650. [CrossRef] [PubMed]
 
Braissant, O, Foufelle, F, Scotto, C, et al Differential expression of peroxisome proliferator-activated receptors: tissue distribution of PPARα, β and γ in the adult rat.Endocrinology1996;137,354-366. [CrossRef] [PubMed]
 
Vamecq, J, Latruffe, N Medical significance of peroxisome proliferator-activated receptors.Lancet1999;354,141-148. [CrossRef] [PubMed]
 
Kubota, T, Koshizuka, K, Williamson, EA, et al Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer bothin vitroandin vivo.Cancer Res1998;58,3344-3352. [PubMed]
 

Figures

Tables

References

Stefanec, T (2000) Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease?Chest117,841-854. [CrossRef] [PubMed]
 
Bishop-Bailey, D, Hla, T Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-delta 12, 14-prostaglandin J 2.J Biol Chem1999;274,17042-17048. [CrossRef] [PubMed]
 
Issemann, I, Green, S Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.Nature1990;347,645-650. [CrossRef] [PubMed]
 
Braissant, O, Foufelle, F, Scotto, C, et al Differential expression of peroxisome proliferator-activated receptors: tissue distribution of PPARα, β and γ in the adult rat.Endocrinology1996;137,354-366. [CrossRef] [PubMed]
 
Vamecq, J, Latruffe, N Medical significance of peroxisome proliferator-activated receptors.Lancet1999;354,141-148. [CrossRef] [PubMed]
 
Kubota, T, Koshizuka, K, Williamson, EA, et al Ligand for peroxisome proliferator-activated receptor γ (troglitazone) has potent antitumor effect against human prostate cancer bothin vitroandin vivo.Cancer Res1998;58,3344-3352. [PubMed]
 
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