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Clinical Investigations: ASTHMA |

Comparison of the Effects of Single Oral Doses of Nebivolol and Celiprolol on Airways in Patients With Mild Asthma*

Mario Cazzola, MD, FCCP; Paolo Noschese, MD; Maria D’Amato, MD; Gennaro D’Amato, MD
Author and Funding Information

*From the Divisione di Pneumologia e Allergologia, Ospedale A. Cardarelli, Napoli, Italy.

Correspondence to: Mario Cazzola, MD, FCCP, Via del Parco Margherita 24, 80121 Napoli, Italy; e-mail: mcazzola@qubisoft.it



Chest. 2000;118(5):1322-1326. doi:10.1378/chest.118.5.1322
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Objective: The respiratory effects of nebivolol, a new selective β1-adrenergic blocking agent, and celiprolol, aβ -blocker possessing strong β1-adrenoceptor antagonist and mild β2-agonist properties, were investigated in 12 patients with mild asthma.

Design: Changes in several spirometric indexes (FVC, FEV1, and forced expiratory flow rate at 50% of FVC) were measured. The interaction with the bronchodilator effect of the β2-adrenoceptor-selective agonist albuterol also was investigated.

Results: The effect of both nebivolol and celiprolol on FEV1 was considered to be significant (p < 0.05). The administration of nebivolol and celiprolol, but not of placebo, elicited a decrease in FEV1: mean maximum difference for nebivolol, −0.272 L (95% confidence interval [CI], −0.402 to −0.142); mean maximum difference for celiprolol, −0.193 L (95% CI, −0.316 to −0.071); mean maximum difference for placebo, −0.0001 L (95% CI, −0.087 to 0.085). The inhalation of albuterol, up to a dose of 800 μg, significantly (p < 0.05) improved FEV1, but the values after nebivolol and celiprolol administration were lower than the initial values. Both β-blockers caused equal changes in heart rate, systolic BP, and diastolic BP.

Conclusions: There were no significant differences between the respiratory actions of the two active drugs.

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