0
Clinical Investigations: ASTHMA |

Atopy Influences Exhaled Nitric Oxide Levels in Adult Asthmatics*

Ling-Pei Ho, MD; Fraser T. Wood, MRCP; Andrew Robson, PhD; J. Alastair Innes, PhD; Andrew P. Greening, FRCP
Author and Funding Information

*From the Respiratory Unit (Drs. Wood, Robson, Innes, and Greening), Western General Hospital, Edinburgh, and Osler Chest Unit (Dr. Ho), Churchill Hospital, Oxford, United Kingdom.

Correspondence to: Ling-Pei Ho, MD, Osler Chest Unit, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom



Chest. 2000;118(5):1327-1331. doi:10.1378/chest.118.5.1327
Text Size: A A A
Published online

Study objective: To examine whether atopy influences exhaled nitric oxide (NO) levels in adults with established asthma.

Setting: Specialist respiratory unit in a university teaching hospital.

Patients: Twenty-eight asthmatics (mean FEV1, 85.7%) receiving short-acting inhaled bronchodilators and a range of inhaled steroids (0 to 4,000μ g/d).

Interventions: Subjects were studied on two occasions, 5 to 7 days apart, between September and March.

Measurements and results: On the first day, FEV1, exhaled NO, and histamine challenge were performed. On the second day, exhaled NO, total IgE, and skin-prick testing to six common allergens were conducted. Exhaled NO was measured with the single exhalation method. We found exhaled NO levels to correlate positively with total IgE (r = 0.43, p = 0.02) and number of positive skin-prick tests (p = 0.002). By contrast, there was no significant correlation between exhaled NO and FEV1 or the provocative concentration causing a 20% fall in FEV1. Subanalyses of steroid-treated and steroid-naive patients in this group revealed the same findings.

Conclusion: Exhaled NO levels in asthmatics correlate more closely with atopy than with bronchial hyperreactivity and lung function.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543