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Recreational Use of Aminorex and Pulmonary Hypertension*

Seán P. Gaine, MD, FCCP; Lewis J. Rubin, MD, FCCP; James J. Kmetzo, MD; Harold I. Palevsky, MD, FCCP; Thomas A. Traill, MD
Author and Funding Information

*From the Division of Pulmonary and Critical Care Medicine (Dr. Gaine), Division of Cardiology (Dr. Traill), Johns Hopkins University, Baltimore, MD; the Division of Pulmonary and Critical Care Medicine (Dr. Rubin), University of California at San Diego, San Diego, CA; the Division of Cardiology (Dr. Kmetzo), Doylestown Hospital, Doylestown, PA; and the Division of Pulmonary and Critical Care Medicine (Dr. Palevsky), University of Pennsylvania, Philadelphia, PA.

Correspondence to: Lewis J. Rubin MD, FCCP, Division of Pulmonary and Critical Care Medicine, University of California at San Diego, San Diego, CA



Chest. 2000;118(5):1496-1497. doi:10.1378/chest.118.5.1496
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Pulmonary hypertension has been associated with ingestion of the appetite suppressant aminorex. A similar compound, 4-methyl-aminorex (street names, “U-4-E-uh” [pronounced euphoria] or “ice”), is a “designer” drug with central stimulant activity. This drug was discovered on the property of three individuals with diagnoses of pulmonary hypertension. The association between “recreational” aminorex manufacture and ingestion and the development of pulmonary hypertension is described.

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