Pulmonary hypertension has been associated with ingestion of the
appetite suppressant aminorex. A similar compound, 4-methyl-aminorex
(street names, “U-4-E-uh” [pronounced euphoria] or “ice”), is
a “designer” drug with central stimulant activity. This drug was
discovered on the property of three individuals with diagnoses of
pulmonary hypertension. The association between “recreational”
aminorex manufacture and ingestion and the development of pulmonary
hypertension is described.