There is no satisfactory treatment available for HUVS-related COPD,
although many drugs have been tried. These include prednisone,
dapsone, antihistamines (H1- and
H2-blockers), hydroxychloroquine, colchicine,
indomethacin, pentoxifylline, cyclophosphamide, and azathioprine.
High-dose prednisone, with or without a cytotoxic agent or
dapsone, may improve the prognosis when given early in the development
of airway obstruction. Based on one case report of a patient whose
pulmonary disease responded to dapsone, it was suggested that dapsone
should be used as a first-line drug for HUVS, although another case
report described a patient with severe COPD that progressed despite
treatment with dapsone.