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Clinical Investigations: SARCOIDOSIS |

Human Herpesvirus 8 Is Not Associated With Sarcoidosis in Japanese Patients*

Hiroyoshi Maeda, MD; Takashi Niimi, MD; Shigeki Sato, MD; Haruhiko Kawaguchi, MD; Yoshiki Sugiura, MD; Shigeo Mori, MD; Ryuzo Ueda, MD
Author and Funding Information

*From the Second Department of Internal Medicine (Drs. Maeda, Niimi, Sato, Kawaguchi, Sugiura, and Ueda), Nagoya City University Medical School, Nagoya, Japan; and the Department of Pathology (Dr. Mori), Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Correspondence to: Dr. Hiroyoshi Maeda, Second Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.



Chest. 2000;118(4):923-927. doi:10.1378/chest.118.4.923
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Study objectives: The etiology of sarcoidosis remains unknown, but recently it was reported that human herpesvirus 8 (HHV-8) may be detected in sarcoid tissue in a high proportion of patients. This study was performed to determine whether HHV-8 is implicated in sarcoidosis in Japan.

Materials and methods: Peripheral blood mononuclear cells (PBMCs) were obtained from 100 patients with sarcoidosis and 100 healthy donors living in central Japan. Additionally, 19 samples of sarcoid tissue, 10 of tuberculous tissue, and 10 of lung cancers were examined. DNA was extracted from PBMC or tissue samples, and a hemi-nested polymerase chain reaction assay was performed for HHV-8 detection.

Results: In the PBMC study, the detection rates for HHV-8 in patients with sarcoidosis and in normal donors were 2% and 1%, respectively, the difference not being significant (p > 0.99). In the tissue study, HHV-8 was detected in 10.5% of sarcoid and in 15% of nonsarcoid tissues, again not a significant difference (p > 0.99).

Conclusions: From these results, we conclude that HHV-8 is not implicated in sarcoidosis in Japanese patients.

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