Acute formation of methemoglobin is a life-threatening condition
caused by multiple medications. In this article we report the first
case of methemoglobinemia in a patient with metastatic uterine
leiomyosarcoma, after infusion of ifosfamide chemotherapy. The patient
recovered after prompt diagnosis and treatment of the condition. A
mechanism for the formation of methemoglobin as a result of the
ifosfamide infusion is offered.