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Leptin, Obesity, and Obstructive Sleep Apnea

Paul E. Marik, MD, FCCP
Author and Funding Information

Affiliations: Washington, DC 
 ,  Dr. Marik is Director, Medical Intensive Care Unit, Washington Hospital Center.

Correspondence to: Paul E. Marik, MD, FCCP, Department of Internal Medicine, RM-2A-68, Washington Hospital Center, 110 Irving Street, NW, Washington, DC 20010-2975; e-mail: pem4@mhg.edu



Chest. 2000;118(3):569-571. doi:10.1378/chest.118.3.569
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The United States has the notable distinction of having the highest concentration of obese individuals in the world, with a staggering 55% of the adult population being overweight13 The body mass index (BMI; weight in kilograms divided by the square of height in meters) is widely used to distinguish between obese and nonobese adults. Overweight is defined as a BMI measure of 25.0 to 29.9 and obesity as a BMI measure of 30.0 or greater. Excess weight is a major health hazard, with the risk of death from all causes, cardiovascular disease, and cancer increasing throughout the range of moderate and severe overweight for both men and women in all age groups.4 In recent years, body circumference indexes (eg, waist circumference, waist-to-height circumference ratio, waist-to-hip circumference ratio) have been advocated because they can identify adults with a central (android) pattern of obesity, who are at higher risk of obesity-related health problems, independent of the BMI.6

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