Background: Intracardiac thrombus formation is a rare
but serious complication of Behçet’s disease. We aimed to review
the clinical and pathologic correlates of cardiac thrombus formation in
the context of Behçet’s disease.
results: A comprehensive search of the medical literature was
conducted using MEDLINE including bibliographies of all selected
articles. Although the disease has a unique geographic distribution,
being most common in the population of the ancient Silk Route, cases
complicated by intracardiac thrombus have mostly originated from the
Mediterranean basin and the Middle East. Young men appear to be most at
risk, with the right heart the most frequent site of involvement. The
first symptoms and signs of the disease frequently precede systemic
organ manifestations. In those cases in which intracardiac thrombus
occurs, it is apparent in more than half of cases on first recognition
of the disease.
Conclusion: A diagnosis of
Behçet’s disease should be considered if a patient presents with
a mass in the right-sided cardiac chambers, even in the absence of the
characteristic clinical features of the condition. This is particularly
applicable if the patient is a young man from the Mediterranean basin
or the Middle East.