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Talc Granulomatosis*: A Differential Diagnosis of Interstitial Lung Disease in HIV Patients

Daniel N. Nan, MD; Marta Fernández-Ayala, MD; Luis Iglesias, MD; Daniel García-Palomo, MD; Jose A. Parra, MD; M. Carmen Fariñas, MD
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*From the Infectious Diseases Unit, Department of Internal Medicine (Drs. Nan, Fernández-Ayala, Iglesias, García-Palomo, and Fariñas), Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain; and the Radiology Service (Dr. Parra), Hospital Sierrallana, Torrelavega, Spain.

Correspondence to: M. Carmen Fariñas, MD, Infectious Diseases Unit, Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, Avd Valdecilla, s/n, 39008 Santander, Spain; e-mail: mirfac@humv.es



Chest. 2000;118(1):258-260. doi:10.1378/chest.118.1.258
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Consumers of adulterated drugs may present with talc-induced interstitial lung disease. A transbronchial biopsy specimen showing granulomas with intracellular talc crystals is necessary to confirm this diagnosis. In patients infected with HIV, such a condition can be indistinguishable at first glance from opportunistic infections or other pulmonary diseases. A case is presented of a seropositive patient whose chest radiographs showed a diffuse interstitial pattern.

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