Consumers of adulterated drugs may present with talc-induced
interstitial lung disease. A transbronchial biopsy specimen showing
granulomas with intracellular talc crystals is necessary to confirm
this diagnosis. In patients infected with HIV, such a condition can be
indistinguishable at first glance from opportunistic infections or
other pulmonary diseases. A case is presented of a seropositive patient
whose chest radiographs showed a diffuse interstitial pattern.