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Recurrent, Self-Limited, Menstrual-Associated Bronchiolitis Obliterans Organizing Pneumonia*

Mordechai Yigla, MD; Ofer Ben-Itzhak, MD; Anna Solomonov, MD; Luda Guralnik, MD; Ilana Oren, MD
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*From the Division of Pulmonary Medicine (Drs. Yigla and Solomonov), the Department of Pathology (Dr. Ben-Itzhak), the Department of Diagnostic Radiology (Dr. Guralnik), and the Department of Internal Medicine A (Dr. Oren), Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Correspondence to: Mordechai Yigla, MD, Division of Pulmonary Medicine, Rambam Medical Center, POB 9602, Haifa 31096, Israel; e-mail: m_yigla@rambam.health.gov.il



Chest. 2000;118(1):253-256. doi:10.1378/chest.118.1.253
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A 39-year-old woman presented with recurrent acute illness, characterized by high-grade fever, pleuritic chest pain, and unilateral nodular infiltrate on chest radiograph. During the follow-up period, there were six similar episodes, each starting 2 to 3 days prior to her menstrual period and resolving within 5 to 10 days. Persistent symptoms in the seventh episode led us to perform an open lung biopsy; the specimen showed histologic changes compatible with the diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP). To the best of our knowledge, this is the first report describing BOOP in association with a menstrual period. This exceptional case emphasizes the wide and unexpected spectrum of this disease.

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