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Clinical Investigations: CYSTIC FIBROSIS |

International Comparison of Median Age at Death From Cystic Fibrosis*

Andrew Fogarty, BD BCh; Richard Hubbard, DM; John Britton, MD
Author and Funding Information

*From the Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham, UK.

Correspondence to: Andrew Fogarty, BM BCh, University of Nottingham, Division of Respiratory Medicine, City Hospital, Nottingham, NG5 1PB, UK; e-mail: andrew.fogarty@nottingham.ac.uk



Chest. 2000;117(6):1656-1660. doi:10.1378/chest.117.6.1656
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Study objectives: To compare international trends in mortality from cystic fibrosis.

Design: Comparison of trends in median age at death using national mortality data.

Setting: Data from 10 countries in North America, Europe, and Australasia.

Participants: All persons registered as having died of cystic fibrosis in specified years from 1980 to 1994.

Interventions: Comparison of relative odds of death at the international median age at death for the year of death between countries for two periods of time; from 1980 to 1987 (10 countries) and from 1980 to 1994 (7 countries).

Measurements and results: The international median age at death increased from 8 years in 1974 to 21 years in 1994. Median age at death also increased within all countries, was consistently highest in the United States, and varied significantly by a factor of > twofold between countries. Women were significantly more likely to die at a younger age than the median age at death than men.

Conclusions: Median age at death from cystic fibrosis is increasing, but our findings imply that clinically significant differences in survival with cystic fibrosis persist between countries.

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