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Editorials |

Fluid Balance in Sepsis : Are We Ready for a Negative Balance?

Joseph Varon, MD, FCCP; Robert E. Fromm, Jr., MD, MPH, FCCP
Author and Funding Information

Affiliations: Houston, TX
 ,  Drs. Varon and Fromm are from the Sections of Cardiology, Pulmonary and Critical Care, Department of Medicine, Baylor College of Medicine; and Department of Emergency Services, The Methodist Hospital, Houston, TX.

Correspondence to: Joseph Varon, MD, FCCP, Department of Emergency Services, The Methodist Hospital, 6565 Fannin St, MS M-196, Houston, TX 77030; e-mail: jvaron@bcm.tmc.edu



Chest. 2000;117(6):1535-1536. doi:10.1378/chest.117.6.1535
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In recent decades, the incidence of the sepsis syndrome has increased dramatically, largely due to an increased number of invasive procedures being performed, immunosuppressive therapy, and the advancing age of the population. Statistics from the Centers for Disease Control and Prevention have shown that mortality from sepsis has increased 13-fold from 1950 to 1991.12 In the United States, it has been estimated that there are approximately 500,000 new episodes of sepsis each year, with an associated 35% crude mortality rate.1,36

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