A renewed interest in the clinical and pathogenic aspects of COPD
exacerbation is timely in view of national and global COPD initiatives.
The three big problems regarding COPD continue to be the following:
prevention of the disease; slowing progression of the disease once
diagnosis has been established; and prevention and more
effective treatment of the so-called exacerbation. The following
assessment will raise more questions than answers and will review some
of the past and current concepts and contexts.