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The Role of Haemophilus parainfluenzae in COPD*

Susan L. Hill, PhD; J. L. Mitchell; Robert A. Stockley, MD; Robert Wilson, MD
Author and Funding Information

*From the Department of Respiratory Medicine (Drs. Hill, Mitchell, and Stockey), Queen Elizabeth Hospital, Birmingham; and Host Defence Unit (Dr. Wilson), Royal Brompton Hospital, London, UK.

Correspondence to: Susan L. Hill, PhD, Lung Investigation Unit, 1st Floor Nuffield House, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2th, UK



Chest. 2000;117(5_suppl_1):293S. doi:10.1378/chest.117.5_suppl_1.293S
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Extract

Abbreviations: HPI = Haemophilus parainfluenzae; NTHI = nontypeable Haemophilus influenzae; OMP = outer membrane protein

The role of Haemophilus parainfluenzae (HPI) in COPD infection is unclear, in contrast to the accepted pathogenicity of its close relative nontypeable Haemophilus influenzae (NTHI). We have examined the incidence of HPI in patients with COPD and assessed its interaction with host defense systems and with respiratory epithelium.

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