Abbreviations: AMP = adenosine 5′-monophosphate; BHR =
is often accompanied by bronchial hyperresponsiveness (BHR).
Measurement of BHR may yield information about airway inflammation, and
it has been suggested that indirect stimuli might have a closer
relation with inflammation than direct stimuli such as histamine or
methacholine. In order to get a better understanding of the role of BHR
to adenosine 5′-monophosphate (AMP) in COPD, we investigated
inflammatory indices in induced sputum, BAL fluid, and bronchial
biopsies. We studied 18 nonatopic, nonreversible subjects with COPD, 12
with BHR to AMP (mean ± SD age, 63 ± 8 years; FEV1
percent predicted, 56 ± 13%), and 6 without BHR to AMP
(mean ± SD age, 60 ± 6 years; FEV1 percent predicted,
65 ± 11%), and compared these with 11 healthy nonatopic control
subjects (mean ± SD age, 58 ± 8 years; FEV1 percent
predicted, 104 ± 11%).