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Airway Inflammation and Hyperresponsiveness to Adenosine 5′-Monophosphate in COPD*

Steven R. Rutgers, MD; Huib AM Kerstjens, MD; Wim Timens, MD; Nikolaos Tzanakis, MD; Henk F. Kauffman, PhD; Dirkje S. Postma, MD
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*From the Departments of Pulmonary Diseases (Mr. Rutgers and Drs. Kerstjens and Postma), Pathology (Dr. Timens), and Allergology (Dr. Tzanakis), University Hospital Groningen, the Netherlands, and the Department of Pulmonary Disease (Dr. Kauffman), University Hospital, Crete, Greece.

Correspondence to: Steven R. Rutgers, MD, Department of Pulmonary Diseases, University Hospital Groningen, POB 30.001, 9700 RB Groningen, Netherlands



Chest. 2000;117(5_suppl_1):285S. doi:10.1378/chest.117.5_suppl_1.285S
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Extract

Abbreviations: AMP = adenosine 5′-monophosphate; BHR = bronchial hyperresponsiveness

COPD is often accompanied by bronchial hyperresponsiveness (BHR). Measurement of BHR may yield information about airway inflammation, and it has been suggested that indirect stimuli might have a closer relation with inflammation than direct stimuli such as histamine or methacholine. In order to get a better understanding of the role of BHR to adenosine 5′-monophosphate (AMP) in COPD, we investigated inflammatory indices in induced sputum, BAL fluid, and bronchial biopsies. We studied 18 nonatopic, nonreversible subjects with COPD, 12 with BHR to AMP (mean ± SD age, 63 ± 8 years; FEV1 percent predicted, 56 ± 13%), and 6 without BHR to AMP (mean ± SD age, 60 ± 6 years; FEV1 percent predicted, 65 ± 11%), and compared these with 11 healthy nonatopic control subjects (mean ± SD age, 58 ± 8 years; FEV1 percent predicted, 104 ± 11%).

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