Abbreviations: BMI = body mass index;
HRCT = high-resolution CT
Background: A number of uncontrolled reports have suggested
that prior to the development of AIDS-related pulmonary complications,
individuals infected with HIV may develop an accelerated form of lung
damage consistent with an emphysema-like process. Confirming this
observation may have important implications for our understanding of
Methods: We prospectively evaluated 114 clinically stable
HIV-positive subjects with high-resolution CT (HRCT) of the chest.
Forty-four HIV-negative subjects matched for age and smoking history
served as control subjects. Scans were interpreted for the presence and
severity of emphysema. BAL was performed in agreeable subjects to
exclude occult opportunistic infection and to examine cellular
characteristics that might be correlated with emphysema development.