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HIV Infection Increases Susceptibility to Smoking-Induced Emphysema*

Philip T. Diaz, MD; Eric R. King, MD; Mark D. Wewers, MD; James E. Gadek, MD; David Neal, MD; Janice Drake; Thomas L. Clanton, PhD
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*From Ohio State University, Columbus, OH.

Correspondence to: Philip T. Diaz, MD, Division of Pulmonary and Critical Care Medicine, Ohio State University Medical Center, N325 Means Hall, 1654 Upham Dr, Columbus, OH 43210-1228



Chest. 2000;117(5_suppl_1):285S. doi:10.1378/chest.117.5_suppl_1.285S
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Abbreviations: BMI = body mass index; HRCT = high-resolution CT

Background: A number of uncontrolled reports have suggested that prior to the development of AIDS-related pulmonary complications, individuals infected with HIV may develop an accelerated form of lung damage consistent with an emphysema-like process. Confirming this observation may have important implications for our understanding of emphysema pathogenesis.

Methods: We prospectively evaluated 114 clinically stable HIV-positive subjects with high-resolution CT (HRCT) of the chest. Forty-four HIV-negative subjects matched for age and smoking history served as control subjects. Scans were interpreted for the presence and severity of emphysema. BAL was performed in agreeable subjects to exclude occult opportunistic infection and to examine cellular characteristics that might be correlated with emphysema development.

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