0
Articles |

Nutrition and Metabolism in COPD*

Emiel F.M. Wouters, MD, PhD, FCCP
Author and Funding Information

*From the Department of Pulmonology, University Maastricht, Maastricht, The Netherlands.

Correspondence to: Emiel F.M. Wouters, MD, PhD, FCCP, Department of Pulmonology, University Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands; e-mail: ewo@slon.azm.nl



Chest. 2000;117(5_suppl_1):274S-280S. doi:10.1378/chest.117.5_suppl_1.274S
Text Size: A A A
Published online

Extract

Abbreviations: ADP = adenosine diphosphate; ATP = adenosine triphosphate; BMC = bone mineral content; BMI = body mass index; COX = cytochrome oxidase; FFM = fat free mass; GLU = glutamate; IMP = inosine monophosphate; MHC = myosin heavy chain; MLC = myosin light chain; NAD = nicotinamide adenine dinucleotide; NADH = reduced NAD; PCr = creatine phosphate; Pi = inorganic phosphate; REE = resting energy expenditure; sTNF-R = soluble TNF-receptor; TNF = tumor necrosis factor

1Filey, GF, Beckwitt, HJ, Reeves, JT, et al (1968) Chronic obstructive bronchopulmonary disease.Am J Med44,26-392Schols, AM, Scoeters, PB, Mostert, R, et al Energy balance in chronic obstructive pulmonary disease.Am Rev Respir Dis1991;143,1248-12523Engelen, MP, Schols, AM, Baken, WC, et al Nutritional depletion in relation to respiratory and peripheral skeletal muscle function in out-patients with COPD.Eur Respir J1994;7,1793-17974Wilson, DO, Rogers, RM, Sanders, MH, et al Nutritional intervention in malnourished patients with emphysema.Am Rev Respir Dis1986;134,672-6775Bernard, S, LeBlanc, P, Whittom, F, et al Peripheral muscle weakness in patients with chronic obstructive pulmonary disease.Am J Respir Cir Care Med1998;158,629-6346Baarends, EM, Schols, AM, Mostert, R, et al Peak exercise response in relation to tissue depletion in patients with chronic obstructive pulmonary disease.Eur Respir J1997;10,2807-28137Schols AM, Mostert R, Soeters PB, et al. Body composition and exercise performance in patients with chronic obstructive pulmonary disease. Thorax 1991; 46;695–6998Yoshikawa, M, Yoned, T, Kobayashi, A, et al Body composition analysis by dual energy x-ray absorptiometry and exercise performance in underweight patients with COPD.Chest1999;115,371-3759Shoup, R, Dalsky, G, Warner, S, et al Body composition and health-related quality of life in patients with obstructive airways disease.Eur Respir J1997;10,1576-158010Goris, A, Schols, A, Weling-Scheepers, C, et al Tissue depletion in relation to physical function and quality of life in patients with severe chronic obstructive pulmonary disease.Clin Nutr1997;16,P6211Engelen, J, Schols, A, Lamers, R, et al Different patterns of chronic tissue wasting among emphysema and chronic bronchitis patients.Clin Nutr1999;18,275-28012Klein, JS, Gamsu, G, Webb, WR, et al High-resolution CT diagnosis of emphysema in symptomatic patients with normal chest radiographs and isolated low diffusing capacity.Radiology1992;182,817-82113Lamers, RJ, Thelissen, GR, Kessels, AG, et al Chronic obstructive pulmonary disease: evaluation with spirometrically controlled CT lung densitometry.Radiology1994;193,109-11314Engelen, M, Schols, A, Does, J, et al Skeletal muscle weakness is predominantly the consequence of extremity fat-free mass wasting but not of airflow obstruction in patients with chronic obstructive pulmonary disease.Am J Clin Nutr2000;71,733-73815Auwerx, L, Staels, B Leptin.Lancet1998;351,737-74216Flier, J Leptin expression and action: new experimental paradigms.Proc Natl Acad Sci1997;94,4242-424517Lord, G, Matarese, G, Howard, J, et al Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression.Nature1998;394,897-90118Takabatake, N, Nakamura, H, Abe, S, et al Circulating leptin in patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med1999;159,1215-121919Schols, A, Creutzberg, E, Buurman, W, et al Plasma leptin is related to pro-inflammatory status and dietary intake in patients with COPD.Am J Respir Crit Care Med1999;160,1220-122620Schols, AM, Fredix, EW, Soeters, PB, et al Resting energy expenditure in patients with chronic obstructive pulmonary disease.Am J Clin Nutr1991;54,983-98721Donahoe, M, Rogers, RM Nutritional assessment and support in chronic obstructive pulmonary disease.Clin Chest Med1990;11,487-50422Hugli, O, Schutz, Y, Fitting, J The cost of breathing in stable chronic obstructive pulmonary disease.Clin Sci1995;89,625-63223Pouw, EM, Schols, AM, Deutz, NE, et al Plasma and muscle amino acid levels in relation to resting energy expenditure and inflammation in stable chronic obstructive pulmonary disease.Am J Respir Crit Care Med1998;158,797-80124Schols, AM, Buurman, WA, Staal van den Brekel, AJ, et al Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease.Thorax1996;51,819-82425Creutzberg, EC, Schols, AM, Bothmer, FC, et al Acute effects of nebulized salbutamol on resting energy expenditure in patients with chronic obstructive pulmonary disease and in healthy subjects.Respiration1998;65,375-38026Baarends, EM, Schols, AM, Pannemans, DL, et al Total free living energy expenditure in patients with severe chronic obstructive pulmonary disease.Am J Respir Crit Care Med1997;155,549-55427Baarends, EM, Schols, AM, Westerterp, KR, et al Total daily energy expenditure relative to resting energy expenditure in clinically stable patients with COPD.Thorax1997;52,780-78528Baarends, EM, Schols, AM, Akkermans, MA, et al Decreased mechanical efficiency in clinically stable patients with COPD.Thorax1997;52,981-98629Creutzberg, E, Schols, A, Weling-Scheepers, C, et al Characterization of nonresponse to high caloric oral nutritional therapy in depleted patients with COPD.Am J Respir Crit Care Med2000;161,745-75230Mitch, WE, Goldberg, AL Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway.N Engl J Med1996;335,1897-190531Wing, SS, Goldberg, AL Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting.Am J Physiol1993;264,E668-E67632Price, SR, England, BK, Bailey, JL, et al Acidosis and glucocorticoids concomitantly increase ubiquitin and proteasome subunit mRNAs in rat muscle.Am J Physiol1994;267,C955-C96033Li, Y, Schwartz, R, Waddell, I, et al Skeletal muscle myocytes undergo protein loss and reactivate oxygen-mediated NF-kB activation in response to tumor necrosis factor a.FASEB J1998;12,871-88034Satta, A, Migliori, GB, Spanevello, A, et al Fibre types in skeletal muscles of chronic obstructive pulmonary disease patients related to respiratory function and exercise tolerance.Eur Respir J1997;10,2853-286035Owens, GR, Rogers, RM, Pennock, BE, et al The diffusing capacity as a predictory of arterial oxygen desaturation during exercise in patients with chronic obstructive pulmonary disease.N Engl J Med1984;310,1218-122136Kushmerick, M, Meyer, R, Brown, T Regulation of oxygen consumption in fast- and slow-twitch muscle.Am J Physiol1992;263,C598-C60637Meyer, R, Brown, T, Kushmerick, M Phosphorus nuclear magnetic resonance of fast- and slow-twitch muscle.Am J Physiol1985;248,C279-C28738Jakobsson, P, Jorfeldt, L, Brundin, A Skeletal muscle metabolites and fibre types in patients with advanced chronic obstructive pulmonary disease (COPD), with and without chronic respiratory failure.Eur Respir J1990;3,192-19639Levine, S, Kaiser, L, Leferovich, J, et al Cellular adaptations in the diaphragm in chronic obstructive pulmonary disease.N Engl J Med1997;337,1799-180640Casaburi, R, Patessio, A, Ioli, F, et al Reductions in exercise lactic acidosis and ventilation as a result of exercise training in patients with obstructive lung disease.Am Rev Respir Dis1991;143,9-1841Maltais, F, Simard, AA, Simard, C, et al Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD.Am J Respir Crit Care Med1996;153,288-29342Maltais, F, LeBlanc, P, Simard, C, et al Skeletal muscle adaptation to endurance training in patients with chronic obstrucitve pulmonary disease.Am J Respir Crit Care Med1996;154,442-44743Engelen, M, Schols, A, Does, J, et al Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema.Am J Respir Crit Care Med2000;161,98-10344Pison, CM, Chauvin, C, Perrault, H, et al In vivohypoxic exposure impairs metabolic adaptations to a 48-hour fast in rats.Eur Respir J1998;12,658-66545Leverve, X Metabolic and nutritional consequences of chronic hypoxia.Clin Nutr1998;17,241-25146Wallace, DC, Zheng, XX, Lott, MT, et al Familial mitochondrial encephalomyopathy (MERRF): genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease.Cell1988;55,601-61047Orozco Levi, M, Gea, J, Lloreta, JL, et al Subcellular adaptation of the human diaphragm in chronic obstructive pulmonary disease.Eur Respir J1999;13,371-37848Sauleda, J, Garcia Palmer, F, Wiesner, RJ, et al Cytochrome oxidase activity and mitochondrial gene expression in skeletal muscle of patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med1998;157,1413-141749Pouw, EM, Schols, AM, van der Vusse, GJ, et al Elevated inosine monophosphate levels in resting muscle of patients with stable chronic obstructive pulmonary disease.Am J Respir Crit Care Med1998;157,453-45750Dudley, GA, Terjung, RL Influence of aerobic metabolism on IMP accumulation in fast-twitch muscle.Am J Physiol1985;248,C37-C4251Wuyam, B, Payen, JF, Levy, P, et al Metabolism and aerobic capacity of skeletal muscle in chronic respiratory failure related to chronic obstructive pulmonary disease.Eur Respir J1992;5,157-16252Thompson, CH, Davies, RJ, Kemp, GJ, et al Skeletal muscle metabolism during exercise and recovery in patients with respiratory failure.Thorax1993;48,486-49053Payen, JF, Wuyam, B, Levy, P, et al Muscular metabolism during oxygen supplementation in patients with chronic hypoxemia.Am Rev Respir Dis1993;147,592-59854Stratton, JR, Kemp, GJ, Daly, RC, et al Effects of cardiac transplantation on bioenergetic abnormalities of skeletal muscle in congestive heart failure.Circulation1994;89,1624-163155Kemp, GJ, Thompson, CH, Stratton, JR, et al Abnormalities in exercising skeletal muscle in congestive heart failure can be explained in terms of decreased mitochondrial ATP synthesis, reduced metabolic efficiency, and increased glycogenolysis.Heart1996;76,35-4156Kutsuzawa, T, Shioya, S, Durita, D, et al 31P-NMR study of skeletal muscle metabolism in patients with chronic respiratory impairment.Am Rev Respir Dis1992;146,1019-102457Tada, H, Kato, H, Misawa, T, et al 31P-nuclear magnetic resonance evidence of abnormal sketal muscle metabolism in patients with chronic lung disease and congestive heart failure.Eur Respir J1992;5,163-169

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543