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Polymorphisms of Surfactant Protein Gene A, B, D, and of SP-B-linked Microsatellite Markers in COPD of a Mexican Population*

Xiaoxuan Guo, MD; Hung-Mo Lin, PhD; Zhenwu Lin, PhD; Martha Montaño, MSc; Raul Sansores, MD; Guirong Wang, PhD; Susan DiAngelo, BS; Annie Pardo, PhD; Moises Selman, MD, FCCP; Joanna Floros, PhD
Author and Funding Information

*From the Departments of Cellular and Molecular Physiology (Drs. Zhenwu Lin, Guo, Wang, and DiAngelo) and Pediatrics (Dr. Floros), and Health Evaluation Sciences (Dr. Hung-Mo Lin), Pennsylvania State University College of Medicine, Hershey, PA; Instituto Nacional de Enfermedades Respiratorias (Drs. Sansores and Selmon, Ms. Montaño), and Facultad de Ciencias UNAM (Dr. Pardo), Mexico.

Correspondence to: Joanna Flores, PhD, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033



Chest. 2000;117(5_suppl_1):249S-250S. doi:10.1378/chest.117.5_suppl_1.249S-a
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COPD is a major medical problem and leads to a significant morbidity and mortality among the adult population. Several factors have been suggested as risk factors for COPD, including environmental and genetic, supporting the notion that the etiology of COPD is multifactorial and/or multigenic. One of the important risk factors is cigarette smoking, where a significant number of smokers develop COPD.13 Although inherited deficiency of α1-antitrypsin is one of the documented risk factors, this accounts for < 1% of the COPD cases.,1,4 Other genetic polymorphisms have been associated with increased susceptibility to developing COPD.56 In addition, the expression of the disease itself is complex, ie, some COPD patients may develop predominately airway disease and others parenchymal disease.

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