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Pulmonary Mechanics of Papain Emphysema in Dogs*

Robert E. Hyatt, MD, FCCP; G. Farkas, PhD; M. Schroeder
Author and Funding Information

*From the Mayo Clinic, Rochester, MN. This abstract is funded by HL43865.

Correspondence to: Robert E. Hyatt, MD, FCCP, Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905



Chest. 2000;117(5_suppl_1):246S. doi:10.1378/chest.117.5_suppl_1.246S
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Extract

Papain by intratracheal instillation is said to produce a model of human emphysema. We examined this in 13 dogs receiving 10 to 20 instillations of papain, dissolved in saline solution, over 11 to 13 months. Four control dogs received only saline solution. The dogs were lightly anesthetized during papain delivery and during mechanical studies, which were done during the baseline period and at sacrifice. Measured were total lung capacity, forced vital capacity, functional residual capacity, pulmonary resistance, static compliance and dynamic compliance, maximal flow at 50% forced vital capacity (V̇50), Pao2, and Paco2 (see Table 1). All lungs were formalin-fixed at a pressure of 30 cm H2O. Control dogs showed no change and their data are not tabled.

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