intratracheal instillation is said to produce a model of human
emphysema. We examined this in 13 dogs receiving 10 to 20 instillations
of papain, dissolved in saline solution, over 11 to 13 months. Four
control dogs received only saline solution. The dogs were lightly
anesthetized during papain delivery and during mechanical studies,
which were done during the baseline period and at sacrifice. Measured
were total lung capacity, forced vital capacity, functional residual
capacity, pulmonary resistance, static compliance and dynamic
compliance, maximal flow at 50% forced vital capacity
(V̇50), Pao2, and
Paco2 (see Table 1).
All lungs were formalin-fixed at a pressure of 30 cm H2O.
Control dogs showed no change and their data are not tabled.