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Preliminary Report |

Chronic Infiltrative Lung Diseases*: Value of Gadolinium-Enhanced MRI in the Evaluation of Disease Activity—Early Report

Michele Gaeta, MD; Alfredo Blandino, MD; Emanuele Scribano, MD; Fabio Minutoli, MD; Mario Barone, MD; Filippo Andò, MD; Ignazio Pandolfo, MD
Author and Funding Information

*From the Institutes of Scienze Radiologiche (Drs. Gaeta, Blandino, Scribano, Minutoli, and Pandolfo), Chirurgia Toracica (Dr. Barone), and Malattie Respiratorie (Dr. Andò), University of Messina, Messina, Italy.

Correspondence to: Fabio Minutoli, MD, Viale dei Tigli 25, Messina 98168, Italy



Chest. 2000;117(4):1173-1178. doi:10.1378/chest.117.4.1173
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Study objective: To determine the value of gadolinium-enhanced MRI in the assessment of disease activity in chronic infiltrative lung diseases (CILDs).

Design: Retrospective study.

Setting: University hospital.

Materials and Methods: Twenty-five consecutive patients with CILD were studied. The following diseases were diagnosed: sarcoidosis (n = 10), bronchiolitis obliterans organizing pneumonia (n = 3), usual interstitial pneumonia (n = 4), radiation pneumonia (n = 2), desquamative interstitial pneumonia (n = 1), rheumatoid lung (n = 1), vasculitis (n = 1), alveolar proteinosis (n = 1), bronchioloalveolar carcinoma (n = 1), and chronic eosinophilic pneumonia (n = 1). In each patient, the disease activity was assessed by one or more of the following studies: BAL (n = 18), gallium-radioisotope lung scanning (n = 6), serum angiotensin-converting enzyme assay (n = 10), and open lung biopsy (n = 4). T1-weighted breath-hold MRI studies were obtained before and after IV injection of gadolinium. The MRI examinations were analyzed to assess the presence or absence of lesional enhancement.

Results: The presence of enhanced pulmonary lesions was seen in 14 patients. All of these patients had active disease. Of the 17 patients with active disease, 14 had enhanced lesions, and 3 had unenhanced lesions. Pulmonary lesions were not enhanced in any patients with inactive disease. The difference was statistically significant (Fisher Exact Test, p < 0.05).

Conclusion: Gadolinium-enhanced MRI may prove to be a useful tool in assessing disease activity in CILDs.

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