Study objectives: To determine the relationship between
D dimer (DD) status and markers of disease activity in patients with
Design: Prospective, observational
Setting: Pulmonary clinic of a tertiary
care, university-affiliated hospital.
Consecutive individuals with newly diagnosed sarcoidosis.
Intervention: Determination of serum DD.
Measurements and results: The study cohort included 28
subjects, and DD was present in 39.3%. DD status correlated with the
radiographic stage of disease (p = 0.035), diffusing capacity of the
lung for carbon monoxide (p = 0.026), serum angiotensin-converting
enzyme level (p = 0.006), and the presence of dyspnea (p = 0.034).
Patients with circulating DD were 3.8 times more likely to have
radiographic evidence of interstitial involvement. DD was not
associated with either FVC or the FEV1.
Conclusions: DD is frequently positive in patients with
sarcoidosis. DD is associated with disease activity as measured by
radiograph, pulmonary function tests, and serum markers of