0
Clinical Investigations: SARCOIDOSIS |

Circulating D Dimer in Patients With Sarcoidosis*

Andrew F. Shorr, MD, MPH; Oleh W. Hnatiuk, MD, FCCP
Author and Funding Information

*From the Pulmonary & Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC.

Correspondence to: Andrew Shorr, MD, MPH, Pulmonary & Critical Care Medicine, Walter Reed Army Medical Center, 6900 Georgia Ave, NW, Washington, DC 20307; e-mail: AFShorr@DNAMAIL.com



Chest. 2000;117(4):1012-1016. doi:10.1378/chest.117.4.1012
Text Size: A A A
Published online

Study objectives: To determine the relationship between D dimer (DD) status and markers of disease activity in patients with sarcoidosis.

Design: Prospective, observational analysis.

Setting: Pulmonary clinic of a tertiary care, university-affiliated hospital.

Patients: Consecutive individuals with newly diagnosed sarcoidosis.

Intervention: Determination of serum DD.

Measurements and results: The study cohort included 28 subjects, and DD was present in 39.3%. DD status correlated with the radiographic stage of disease (p = 0.035), diffusing capacity of the lung for carbon monoxide (p = 0.026), serum angiotensin-converting enzyme level (p = 0.006), and the presence of dyspnea (p = 0.034). Patients with circulating DD were 3.8 times more likely to have radiographic evidence of interstitial involvement. DD was not associated with either FVC or the FEV1.

Conclusions: DD is frequently positive in patients with sarcoidosis. DD is associated with disease activity as measured by radiograph, pulmonary function tests, and serum markers of inflammation.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543