Study objectives: To evaluate Vivostat fibrin sealant
in the prevention of air leakage after experimental lung resection in
Design: Randomized study.
Setting: University laboratory.
Six Landrace pigs were operated on in both lungs through a median
sternotomy. Five different resection sites were created in each
Intervention: Randomization was performed to
either application of Vivostat fibrin sealant (ConvaTec; Skillman NJ)
or human albumin 20% (control) at the resection sites. The lung
parenchyma was occluded with a soft clamp for either 1, 2, 5, or 10 min
in the treatment group and 10 min in the control group. After removal
of the clamp, the lung was ventilated with an increasing intrabronchial
pressure of 20, 30, and 45 cm H2O for 2 min at each
Results: At inspiratory pressures of 20 and 30
cm H2O air leaks were found in the control group but not in
the Vivostat group (p < 0.001). At an inspiratory pressure of 45 cm
H2O, there were two small air leaks in the Vivostat group
at each clamping time (four at 5 min), compared with five small and
seven large leaks in the control group. Analysis of the data after 10
min of clamping showed that the Vivostat group was superior to the
human albumin group (p = 0.002).
randomized study shows that Vivostat fibrin sealant is effective in
preventing air leakage after small lung resections in pigs, even at
high inspiratory pressures.