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Clinical Investigations: Miscellaneous |

Sex Differences in Left Ventricular Geometry in Aortic Stenosis*: Impact on Outcome

Donna L. Milavetz, MD; Sharonne N. Hayes, MD; Susan A. Weston, MS; James B. Seward, MD; Charles J. Mullany, MB, MS; Véronique L. Roger, MD, MPH
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*From the Division of Cardiovascular Diseases and Internal Medicine (Drs. Milavetz, Hayes, Seward, and Roger), the Section of Biostatistics (Ms. Weston), and the Division of Thoracic and Cardiovascular Surgery (Dr. Mullaney), Mayo Clinic and Mayo Foundation, Rochester, MN.

Correspondence to: Veronique L. Roger, MD, MPH, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905



Chest. 2000;117(4):1094-1099. doi:10.1378/chest.117.4.1094
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Objective: This study of surgical aortic stenosis characterized sex differences in left ventricular (LV) geometry and outcome.

Materials and methods: We examined 92 women and 82 men who underwent echocardiography before valve replacement for aortic stenosis.

Results: Women had a smaller cavity size (LV end-diastolic diameter 48.2 ± 7 mm in women vs 53.6 ± 7.6 mm in men; p = 0.0001) and higher ejection fraction (59% in women vs 54% in men; p = 0.02). LV mass was greater in men than women (300.4 ± 88 g in men vs 250.6 ± 85.8g in women; p = 0.0055) but when corrected for body surface area, the difference was not significant. The prevalence of LV hypertrophy was similar in both sexes (51% in women vs 49% in men; p = 0.62). The 5-year survival was 82% in women and 79% in men (p = 0.9).

Conclusion: Several descriptors of LV geometry differed between men and women. These differences were largely eliminated after normalizing for body surface area. No differences in surgical mortality or long-term outcome were noted.

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