0
Clinical Investigations: COPD |

Exhaled Nitric Oxide and Exercise in Stable COPD Patients*

Enrico Clini, MD, FCCP; Luca Bianchi, MD; Michele Vitacca, MD; Roberto Porta, MD; Katia Foglio, MD; Nicolino Ambrosino, MD, FCCP
Author and Funding Information

*From the Pulmonary Division, Lung Function Unit, Fondazione S. Maugeri IRCCS, Gussago (Brescia), Italy.

Correspondence to: Enrico Clini, MD, FCCP, Fondazione Maugeri IRCCS, Via Pinidolo 23, 25064 Gussago (Bs). Italy; e-mail fsm.g2@numerica.it



Chest. 2000;117(3):702-707. doi:10.1378/chest.117.3.702
Text Size: A A A
Published online

Study objective: To evaluate exhaled nitric oxide (eNO) during exercise in patients with stable COPD.

Setting: Outpatient evaluation in a rehabilitation center.

Patients: Eleven consecutive male patients with stable COPD (age, 65 ± 6 years; FEV1, 56 ± 10% predicted). Eight healthy (six men; age, 51 ± 16 years) nonsmoking, nonatopic volunteers served as control subjects.

Methods: In each subject, a symptom-limited cycle ergometry test was performed by monitoring eNO with the tidal-breath method to assess eNO concentration (Feno) and output (V̇no) at rest, peak exercise, and recovery time.

Results: Resting Feno (9.8 ± 5.1 and 14.1 ± 6.3 parts per billion, respectively) and V̇no (4.2 ± 2.0 and 5.9 ± 3.4 nmol/min, respectively) were lower, although not significantly, in COPD patients than in control subjects. In both groups, Feno significantly decreased whereas V̇no significantly increased during exercise. Both variables returned to baseline during the recovery time. Peak exercise V̇no, but not Feno, was significantly lower in COPD patients than in control subjects (7.9 ± 5.4 and 12.7 ± 6.0 nmol/min, respectively, p < 0.05). The rise in V̇no was weakly correlated to oxygen consumption (V̇o2) both in control subjects (r = 0.31, p = 0.002) and in COPD patients (r = 0.22, p = 0.03). Feno showed an inverse correlation to V̇o2 in both groups (r = −0.53, p = 0.000; r = −0.31, p = 0.003 in control subjects and COPD patients, respectively).

Conclusions: In patients with mild and moderate COPD, eNO during exercise parallels that observed in normal control subjects. V̇no, but not Feno, is significantly reduced at peak exercise in COPD patients as compared with control subjects. The long-term effects of exercise training on eNO has to be evaluated by further studies.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543