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Carbamazepine-Induced Systemic Lupus Erythematosus Presenting as Cardiac Tamponade*

Sunil P. Verma, MD, MPH; Nidal Yunis, MD; Andrew Lekos, MD; Robert S. Crausman, MD, FCCP
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*From the Renal Electrolyte and Hypertension Division (Dr. Verma), University of Pennsylvania School of Medicine, Philadelphia, PA; and the Department of Medicine (Drs. Yunis, Lekos, and Crausman), Brown University School of Medicine Providence, RI.

Correspondence to: Sunil P. Verma, MD, MPH, University of Pennsylvania School of Medicine, Renal Electrolyte and Hypertension Division, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104-6144; e-mail: sunilv@att.net



Chest. 2000;117(2):597-598. doi:10.1378/chest.117.2.597
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Here we report the case of a patient who presented with acute cardiac tamponade due to drug-induced systemic lupus erythematosus (SLE). The patient had been treated for a seizure disorder with carbamazepine, a drug that has previously been demonstrated to cause SLE-like syndromes. Further serologic analysis demonstrated the likelihood of drug-induced SLE in this patient, with the rare presentation of cardiac tamponade.

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