Background: Patient compliance, inhalation
devices, and inhalation techniques influence the effectiveness of
Methods: This article presents the
results of a systematic literature review of studies measuring
compliance with inhaled corticosteroids, measuring inhalation technique
with different inhalation devices, and estimating the proportion of
inhaled drug that is deposited in the lung.
Results:Overall, patients took the recommended doses of inhaled
medication on 20 to 73% of days. Frequency of efficient inhalation
technique ranged from 46 to 59% of patients. Education programs have
been shown to improve compliance and inhalation techniques. The lung
deposition achieved with different inhalers depends on particle size as
well as inhaler technique.
Conclusion: This review
demonstrates that multiple factors may come between a prescription of
an inhaled corticosteroid and the arrival of that medicine at its
target organ, the lung.