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Clinical Investigations: CARDIOLOGY |

Beneficial Effect of Short-term Endurance Training on Glucose Metabolism During Rehabilitation After Coronary Bypass Surgery*

Piotr Dylewicz, MD, PhD; Slawomira Bienkowska, MD; Lucja Szczesniak, PhD; Tadeusz Rychlewski, MD, PhD; Izabela Przywarska, MD; Malgorzata Wilk, MSc; Andrzej Jastrzebski, PhD
Author and Funding Information

*From the University School of Physical Education, Institute of Rehabilitation, Department of Cardiac Rehabilitation, Rehabilitation Hospital, Poznan, Poland.

Correspondence to: Piotr Dylewicz, MD, PhD, Rehabilitation Hospital, Department of Cardiac Rehabilitation, ul. Nad Jeziorem 2, 60–480 Poznan, Poland; e-mail: cardreh@soho-online.com



Chest. 2000;117(1):47-51. doi:10.1378/chest.117.1.47
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Aims: Our study was aimed at determining whether beneficial modification of carbohydrate metabolism can be obtained after a short-term training program and whether it is associated with an increase in binding and degradation of 125I-insulin by erythrocyte receptors that suggests a decrease in insulin resistance.

Methods: The study was conducted in a group of 20 patients aged 56 ± 1.9 years (mean ± SEM), within 1 to 6 months after coronary bypass surgery. All patients completed 15 training sessions based on 30 min of cycling with a constant load. Before and after a 3-week training program, glucose, insulin, and C-peptide blood levels, as well as binding and degradation of 125I-insulin by erythrocyte receptors, were determined.

Results: A statistically significant decrease was found in the blood glucose level, from 111.2 ± 4.2 to 97.8 ± 3.5 mg/dL (p < 0.01); this decrease was not accompanied by significant insulin concentration changes. There was also a significant increase in insulin binding, from 0.535 ± 0.059 to 0.668 ± 0.042 pg 125I/1011 RBCs (p < 0.01), and degradation from 7.64 ± 0.54 to 9.49 ± 0.58 pg 125I/1011 RBCs (p < 0.05).

Conclusion: The results indicated that even short-term endurance training in patients rehabilitated after coronary bypass surgery induced favorable modification of glucose metabolism, presumably caused by a decrease in insulin resistance.


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