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Conference Summary*: Acute Lung Injury

Michael A. Matthay, MD, FCCP
Author and Funding Information

*From the University of California, San Francisco, CA.

Correspondence to: Michael A. Matthay, MD, Critical Care Medicine, M-917, University of California, 505 Parnassus Ave, San Francisco, CA 94143-0624; e-mail: mmatt@itsa.ucsf.edu



Chest. 1999;116(suppl_1):119S-126S. doi:10.1378/chest.116.suppl_1.119S
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Extract

The overall objective of this summary will be to highlight the major clinical and experimental work that was presented at the 1998 conference on acute lung injury. This overview will focus on major themes that represent an important link to prior and current research and provide direction for future work in the field.

The summary is divided into five sections. The first section reviews new information regarding definitions and epidemiology of clinical acute lung injury and ARDS. The second section considers experimental and clinical studies that have provided new insights into the pathogenesis of acute lung injury. The third section reviews new data regarding the mechanisms that contribute to the resolution of acute lung injury. The fourth section considers the results of several clinical studies that examined the potential prognostic and pathogenic significance of biological markers that were measured in the plasma, edema fluid, or BAL of patients with or at risk of developing ARDS. The fifth section provides a brief overview of clinical trials that have been completed since the last Aspen Lung Conference on Acute Lung Injury in 1993, as well as a brief discussion of ongoing and potential future clinical trials.


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