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Cellular Alterations in Fibroproliferative Lung Disease*

Galen B. Toews, MD, FCCP
Author and Funding Information

*From the Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 6301 MSRB III, Box 0642, 1150 W Medical Center Dr, Ann Arbor, MI 48109-0642



Chest. 1999;116(suppl_1):112S-116S. doi:10.1378/chest.116.suppl_1.112S
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Extract

A fibroproliferative response begins almost immediately after the onset of acute lung injury in an attempt to repair the damage done to the alveolocapillary wall. Inflammatory cell accumulation and the entry of plasma into the airspaces alters the alveolar microenvironment. Acquired alterations in parenchymal/stromal cell phenotypes likely create tissue environments that either steer the progression of tissue remodeling toward aggressive fibrosis or toward the restoration of normal alveolar architecture. The molecular mechanisms involved in the healing process must be understood if clinicians are to counteract progressive fibrotic responses.


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  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543