0
Articles |

Macrophage Migration Inhibitory Factor and Acute Lung Injury*

S.C. Donnelly; R. Bucala; C.N. Metz; I.S. Grant; C.R. Robertson; C. Haslett
Author and Funding Information

*From the Rayne Laboratory (Drs. Donnelly and Haslett), University of Edinburgh; Picower Institute For Medical Research (Drs. Bucala and Metz), New York, NY; Intensive Care Unit (Dr. Grant), Western General Hospital, Edinburgh; and Accident and Emergency Department (Dr. Robertson), Royal Infirmary Hospital, Edinburgh, Scotland.

Correspondence to: S.C. Donnelly, Respiratory Medicine Unit, Rayne Laboratory, University of Edinburgh, Teviot Place, Edinburgh, Scotland EH8 9AG



Chest. 1999;116(suppl_1):111S. doi:10.1378/chest.116.suppl_1.111S
Text Size: A A A
Published online

Extract

In Edinburgh, we have been interested in delineating early specific inflammatory events associated with ARDS disease progression. We have previously reported that an elevated interleukin-8 (IL-8) level within the alveolar airspaces of patients “at-risk” for ARDS is significantly associated with ARDS disease progression.1 For our trauma “at risk” patients, this was within a mean of 95 min after the initiating trauma event. This rapid upregulation of IL-8 secretion led us to investigate the role of specific members of the neuroendocrine system in this process. As part of this work, we investigated whether migration inhibitory factor (MIF) might play a role in ARDS pathogenesis.


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543