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Alveolar Epithelial Fluid Transport Can Be Upregulated Simultaneously in Rats by Two Different Mechanisms*

Ybing Wang, MD; Christian Jayr, MD; Hans G. Folkesson, PhD; Michael A. Matthay, MD, FCCP
Author and Funding Information

*From the University of California, San Francisco, Cardiovascular Research Institute, San Francisco, CA.

Correspondence to: Michael A. Matthay, MD, FCCP, Cardiovascular Research Institute, 505 Parnassus Ave, HSW-825, San Francisco, CA 94143-0130; e-mail: mmatt@itsa.ucsf.edu



Chest. 1999;116(suppl_1):98S-100S. doi:10.1378/chest.116.suppl_1.98S-a
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Extract

Our laboratory has reported previously that endogenous and exogenous β-adrenergic agonist stimulation can upregulate the rate of alveolar liquid clearance in several species, including sheep, dogs, rats, and mice as well as in the ex vivo human lung.13 Recently, we have also investigated catecholamine-independent mechanisms that can upregulate vectorial sodium and fluid transport across the alveolar epithelium.46 Other investigators have also investigated catecholamine-dependent and independent mechanisms.78


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