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Reduced Growth Factor Expression in Mice Resistant to Developing Fibroproliferative Lesions After Lung Injury*

Arnold R. Brody, PhD; G. Hoyle; J.-Y. Liu; D. Brass
Author and Funding Information

*From the Lung Biology Program, Department of Pathology, Tulane University Medical Center, New Orleans, LA. Supported by NIH grants ES06766 and HL60532.

Correspondence to: Arnold R. Brody, PhD, Lung Biology Program, Tulane University Medical Center, 1430 Tulane Ave, New Orleans, LA 70112-2699



Chest. 1999;116(suppl_1):97S. doi:10.1378/chest.116.suppl_1.97S
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Extract

Following acute lung injury, there is proliferation of multiple cell types, including the alveolar epithelium, endothelium of small vessels, and interstitial fibroblasts. Our work has focused on the expression of selected genes and the cognate proteins that control cell proliferation and extracellular matrix production, the hallmarks of interstitial fibrogenesis. We are studying platelet-derived growth factor (PDGF), transforming growth factors alpha and beta (TGF-α, TGF-β), and tumor necrosis factor alpha (TNF-α). We have shown that these growth factors are expressed rapidly (within the first 5 to 24 h) after the initial alveolar injury caused by inhaled asbestos fibers.


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