0
Articles |

CXC Chemokines Regulate Angiogenic Activity in Acute Lung Injury*

Michael P. Keane, MB, BCh; Carol A. Wilke; Marie D. Burdick; Susan B. Morris; Mary C. Glass; Robert M. Strieter, MD, FCCP
Author and Funding Information

*From the Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI.

Correspondence to: Robert M. Strieter, MD, FCCP, University of Michigan, Pulm/CCM, 6301 MSRB III, 1150 W Medical Ctr, Ann Arbor, MI 48109



Chest. 1999;116(suppl_1):93S-94S. doi:10.1378/chest.116.suppl_1.93S
Text Size: A A A
Published online

Extract

Diffuse alveolar damage (DAD) of ARDS is a stereotypic response to a variety of etiologies.12 The pathologic findings of DAD follow an overlapping continuum of injury: acute exudative phase (approximately days 0 to 4); subacute proliferative phase (approximately days 2 to 8); and chronic fibrotic phase (approximately after day 4).24 This latter phase is associated with ARDS patients who require prolonged mechanical ventilation with both high inflation pressures and increased oxygen requirements.4 In addition, a significant proportion of ARDS survivors appear to have residual pulmonary fibrosis and compromised pulmonary function.57 This suggests that the pathogenesis of DAD that ultimately leads to the chronic fibrosis of ARDS demonstrates features of dysregulated repair with exaggerated intra-alveolar angiogenesis, fibroproliferation, and deposition of extracellular matrix, leading to progressive alveolar fibrosis and impaired lung function. Angiogenesis during DAD is not only a salient feature of the fibroproliferative response, but may represent a mechanism supporting mesenchymal cell proliferation and maintenance of intra-alveolar fibrosis. The mediators that orchestrate this aberrant neovascular response in DAD have not been fully elucidated. Members of the CXC chemokine family exert disparate effects in mediating angiogenesis as a function of the presence or absence of three amino acid residues (Glu-Leu-Arg; the ‘ELR’ motif) in the NH2-terminus of these cytokines.8 CXC chemokines have potent angiogenic (ELR+) and angiostatic (ELR) activity, respectively, and are important factors that regulate angiogenesis in both solid tumors and chronic fibroproliferative disorders.10


Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543